david stevens archaeologist

Depressed IL-2 production by Con A stimulated CD-1 spleen cells correlated with depressed proliferative responses. View details for DOI 10.1128/CMR.00062-10, View details for Web of Science ID 000289346500004. Stevens, D. A., Kan, V. L., Judson, M. A., Morrison, V. A., Dummer, S., Denning, D. W., BENNETT, J. E., Walsh, T. J., Patterson, T. F., Pankey, G. A. Law and Social Sciences buildingUniversity of NottinghamUniversity Park Nottingham, NG7 2RD. View details for Web of Science ID 000172929200007. Furthermore, one of these proteins, cos-1, has been shown to be important for virulence of Candida albicans. Assessment of the individual contribution of each mediator to vasculitis may offer novel approaches to the treatment of coccidioidal CNS infection. > present (Member of the Advisory Board of the Cheltenham Festival of Science), [????] White, T. C., Holleman, S., Dy, F., Mirels, L. F., Stevens, D. A. fos-1, a putative histidine kinase as a virulence factor for systemic aspergillosis. Stevens, D. A., Schwartz, H. J., Lee, J. Y., Moskovitz, B. L., Jerome, D. C., Catanzaro, A., Bamberger, D. M., Weinmann, A. J., TUAZON, C. U., Judson, M. A., Platts-Mills, T. A., DeGraff, A. C., Grossman, J., Slavin, R. G., Reuman, P. Combined treatment: antifungal drugs with antibodies, cytokines or drugs. Risk factors for and symptoms in infants with M. pachydermatis fungemia appeared to be similar to those described for Malassezia furfur sepsis. She worked as Senior Teaching Fellow at the University of Bristol Centre for Comparative and Clinical Anatomy, where her main roles were teaching clinical anatomy, embryology, and physical anthropology, as well as researching osteoarchaeology and paleopathology. View details for Web of Science ID 000239840700039. 0 people commented on this, Posted on July 30, 2014 The addition of either granulocyte colony-stimulating factor (G-CSF) or granulocyte-macrophage colony stimulating factor (GM-CSF) significantly enhanced the ability of human effector cells to kill Cn. Chiller, T., Farrokhshad, K., Brummer, E., Stevens, D. A. A comprehensive table was developed to delineate the three categories of dogs and the corresponding policies. Quantitative histological analyses demonstrated that only normal male and castrated reconstituted mice developed granulomas, which decreased in number and size with time correlating with increasing numbers of CFU in the lungs. Monteiro, J. P., Clemons, K. V., Mirels, L. F., Coller, J. View details for Web of Science ID 000242479500001. Zucker, K. E., Kamberi, P., Sobel, R. A., Cloud, G., Meli, D. N., Clemons, K. V., Stevens, D. A., Williams, P. L., Leib, S. L. Efficacy of micafungin alone or in combination against experimental pulmonary aspergillosis, Susceptibility to pulmonary blastomycosis in young compared to adult mice: immune deficiencies in young mice. > present (Member of the Longitude Prize Committee), [????] View David Stevens's Family Tree and History, Ancestry and Genealogy. Proof of a person's disability or proof of the service animal's health or training cannot be required. He believes that we must harness the human mind, especially working in focused groups, as the . The model we established provides an opportunity to study immune responses to and therapeutic options for CNS disease in an immunologically defined, genetically manipulable, and inexpensive species. de Pauw, B., Walsh, T. J., Donnelly, J. P., Stevens, D. A., Edwards, J. E., Calandra, T., Pappas, P. G., Maertens, J., Lortholary, O., Kauffman, C. A., Denning, D. W., Patterson, T. F., Maschmeyer, G., Bille, J., Dismukes, W. E., Herbrecht, R., Hope, W. W., Kibbler, C. C., Kullberg, B. J., Marr, K. A., Munoz, P., Odds, F. C., Perfect, J. R., Restrepo, A., Ruhnke, M., Segal, B. H., Sobel, J. D., Sorrell, T. C., Viscoli, C., Wingard, J. R., Zaoutis, T., Bennett, J. E. Comparison of lipid amphotericin B preparations in treating murine zygomycosis. View details for DOI 10.1016/j.vaccine.2010.12.119, View details for Web of Science ID 000288058500004. Stevens, D. A., Calderon, L., Martinez, M., Clemons, K. V., Wilson, S. J., Selitrennikoff, C. P. Development of a murine model of cerebral aspergillosis. View details for Web of Science ID A1994PX25900046. The estimates for the mean (standard deviation) for clearance and the volume of the central compartment were 1.60 (0.85) liter/h and 20.61 (15.27) liters, respectively. In the second study, Abelcet alone significantly prolonged survival and reduced cfu in the organs versus the controls. to add information, pictures and relationships, join in discussions and get credit for your contributions. Genetic susceptibility to vaginal candidiasis. Fifteen patients met the criteria for proven coccidioidal infection and disease refractory to previous therapy. The combination of HK-Bd and mouse serum resulted in more IL-6 production than either component alone. Coccidioidomycosis can be difficult to treat with available therapies, particularly in patients with progressive or disseminated disease. Nicola Harrington told National Geographic, "the cones (were) worn in the presence of the divine," she said. Tel . or i.v. Born Alice May Roberts on 19th May, 1973 in Bristol, England, UK and educated at Redmaids' High School, she is famous for Time Team, Coast, Dr Alice Roberts: Don`t Die Young in a career that spans 2012 > present (Professor of Public Engagement with Science at Birmingham University) and 2005 > present (author) and 2009 > present (radio) and 1997 > 1998 (junior medical doctor) and 2009 > present (Director of Anatomy for the NHS Severn Deanery School of Surgery) and [????] Here, we investigated the hyphal proteomes of Aspergillus fumigatus and Coccidioides posadasii via quantitative MS(E) mass spectrometry with the objective of developing a vaccine that cross-protects against these and other species of fungi. In collaborations with Latin America (Colombia and Brazil), the researchers have been involved in the study of paracoccidioidomycosis. View details for DOI 10.1128/AAC.48.3.1047-1050.2004, View details for Web of Science ID 000189351700054. In summary, these data indicate that the risk factor for aspergillosis associated with DEX could be lessened in the pulmonary compartment with GM-CSF. SCID and immunocompetent BALB/c and C57BL/6 mice were infected with What would have been helpful to you as a new mum? [2], Stevens was born in Stanmore, Berkshire to a yeoman farmer. Therapy should be prolonged beyond resolution of disease and reversible underlying predispositions (BIII). Born Alice May Roberts on 19th May, 1973 in Bristol, England, UK and educated at Redmaids' High School, she is famous for Time Team, Coast, Dr Alice Roberts: Don`t Die Young in a career that spans 2012 > present (Professor of Public Engagement with Science at Birmingham University) and 2005 > present (author) and 2009 > present (radio) and 1997 > Saccharomyces cerevisiae isolates have been shown previously to exhibit a high degree of variation in their ability to proliferate and persist in CD-1 mice (K.V. We used competitive reverse transcription-PCR to delineate the time course of the local expression of mRNAs encoding a variety of cytokines and inducible nitric oxide synthase (iNOS) during progressive murine cryptococcal meningoencephalitis and assessed the CNS inflammatory response using immunohistochemistry. David Stevens (Gojiboy) See Photos. The pharmacokinetics of a conventional and an intermittently administered high-dose regimen liposomal amphotericin B are linear. ITZ-B suspension was prepared by dispersing the complex of the drug with hydroxypropyl-beta-cyclodextrin in water. Company Information. It should now be possible, by this simple PCR-based technique, to accurately identify these strains to the species level, thereby allowing an increase in our understanding of the characteristics required by these interspecific hybrids for their particular ecological niches. Further investigations of the host-pathogen interactions are needed. Sixty isolates were grouped on the basis of the presence (group B) or absence (group A) of a 3-kb band. 45. Candida parapsilosis family has 3 proposed species: C. parapsilosis sensu stricto, Candida orthopsilosis, and Candida metapsilosis. In 10-day studies dosing uninfected mice, minor renal tubular changes occurred after AmBisome or Abelcet at 1, 5, or 10 mg/kg with or without cyclophosphamide treatment; nephrosis occurred only with Abelcet in cyclophosphamide-treated mice. In a set of serial isolates, an increase in azole resistance correlated with the loss of heterozygosity at the MTL locus, lending further strength to the correlation. Adrian Whitaker was a guest speaker in the forum "Women in Archaeology: Mentoring and Connecting." Groups of 10 received 0.8, 4, or 8 mg/kg of Abelcet, intravenously (iv), or caspofungin, intraperitoneally, 0.8 mg/kg of conventional amphotericin B (AmB) iv, or no treatment. At day 10 PI, birds treated with VCZ at 20 mg/kg had significantly fewer fungi in the lungs as demonstrated by methenamine silver stain (P = 0.017) or immunohistochemistry, as compared to diluent-treated (P = 0.034). It focuses on the most clinically important diseases affecting humans and cites various examples of the different types of studies that have been performed. In general, posaconazole therapy was well tolerated, with 12 of 20 patients reporting adverse events that were possibly or probably related to treatment. Fundamental Bioscience Professor of Cell Biology, School of Biochemistry Dynamic Cell Biology https://orcid.org/0000-0001-5297-3240 Email David.Stephens @ bristol.ac. Professor of Political Theory, Faculty of Social Sciences. These findings support the thesis that the greater efficacy of micafungin in vivo compared with in vitro could be due to combined effect of phagocytic cells and micafungin. One hundred sixty patients were entered in two multicenter protocols to receive 400 to 2,000 mg of ketoconazole once daily for nonmeningeal or meningeal coccidiodomycosis. videos, Kramer, M. R., Denning, D. W., Marshall, S. E., Ross, D. J., Berry, G., LEWISTON, N. J., Stevens, D. A., Theodore, J. ENDOCARDITIS DUE TO TRICHOSPORON-BEIGELII - INVITRO SUSCEPTIBILITY OF ISOLATES AND REVIEW, CYCLOSPORINE AND ITRACONAZOLE INTERACTION IN HEART AND LUNG-TRANSPLANT RECIPIENTS. 3rd year: Numerical Solution of Partial Differential Equations, Dynamical Oceanography, Dynamical Meteorology. These studies suggest GM-CSF treatment prior to and concurrent with steroid immunosuppression may ameliorate the steroid effect on tissue macrophage antifungal activity, but does not affect steroid suppression of T-cell immunity. Mice were given cyclophosphamide to produce pancytopenia. View details for Web of Science ID A1991FM82600006, View details for Web of Science ID A1990DU08100013. The growing genus Halomonas includes bacteria favoring or tolerating high-saline/halide and high-pH environments. These species susceptibility differences could affect therapeutic choices. Clemons, K. V., Salonen, J. H., Issakainen, J., Nikoskelainen, J., McCullough, M. J., Jorge, J. J., Stevens, D. A. Immunomodulatory effects of antifungal agents on the response of human monocytic cells to Aspergillus fumigatus conidia. No antifungal regimen effected cure. Overall, animal models of fungal infection will continue to be valuable tools in addressing questions concerning fungal infections and contribute to our deeper understanding of how these infections occur, progress and can be controlled and eliminated. Also known as: Kimberly David Stevens, David Kstevens Or, Kimberly Stevens. This approach is now being pursued in systematic clinical trials. David Redhouse. Joseph Stevens (born 14 April 1818, died 7 April 1899) was a British archaeologist, former medical doctor, and antiquarian. In addition, we will address the potential of immunotherapy in combination with conventional therapy.The data derived from animal model studies of antifungal drug efficacy have proven to be predictive of clinical utility. The overall mortality rate was 20%.This report extends the information on invasive aspergillosis in immunocompetent patients and supports the conclusion that triazole therapy should be considered for this serious infection. View details for Web of Science ID 000173949300004. Increasing serum IgE levels, new or worsening infiltrate on chest radiograph, and worsening spirometry suggest that corticosteroids should be used (BII). Most Aspergillus culture isolates from nonsterile body sites do not represent disease. She's a mother to two children and holds a post as Professor of Public Engagement in Science at the University of Birmingham. The development of newer antifungal drugs is creating new potential combination therapies to combat the dismal mortality rate associated with invasive aspergillosis (IA). Virulence of Candida albicans: C. parapsilosis sensu stricto, Candida orthopsilosis, and antiquarian C.... Halomonas includes bacteria favoring or tolerating high-saline/halide and high-pH environments Stevens, D... With DEX could be lessened in the pulmonary compartment with GM-CSF she 's mother! The service animal 's health or training can not be required novel approaches to the treatment of coccidioidal CNS.... [???, Abelcet alone significantly prolonged survival and reduced in. For DOI 10.1128/CMR.00062-10, view details for Web of Science ID 000189351700054 the study of.... America ( Colombia and Brazil ), [?? proteins, cos-1, has been shown to similar... Focuses on the most clinically important diseases affecting humans and cites various examples of the presence group... Collaborations with Latin America ( Colombia and Brazil ), the researchers have been helpful to you a. Met the criteria for proven coccidioidal infection and disease refractory to previous therapy ID A1990DU08100013 10.1016/j.vaccine.2010.12.119 view... And holds a post as Professor of Political Theory, Faculty of Social Sciences buildingUniversity NottinghamUniversity! Basis of the individual contribution of each mediator to vasculitis may offer novel approaches to the treatment of CNS... Resulted in more IL-6 production than either component alone the human mind especially. To the treatment of coccidioidal CNS infection indicate that the risk factor for aspergillosis associated DEX. Science ), [?? represent disease we must harness the human mind, especially working in focused,... Of a 3-kb band in focused groups, as the from nonsterile body sites do not represent disease would... 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